Iñigo Rua-Figueroa, Natalia Pérez-Veiga, Esther Rodríguez-Almaraz, María Galindo-Izquierdo, Celia Erausquin, Antonio Fernandez-Nebro, Esther Uriarte Itzazelaia, Belén Serrano-Benavente, Jaime Calvo ...

Background Abnormalities of type I interferon signaling and production can initiate lupus development. Disturbances of nucleic acid-sensing molecules triggered autoreactivity in lupus mouse models.

Objective BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, and play important roles in the activation, differentiation, and/or survival of B cells, particularly antibody-secreting cells, as ...

Purpose TLR7 and TLR8 (TLR7/8) are members of the Toll-Like Receptor family that recognize single strand RNA. Activation of TLR7/8 within immune cells elevates pro-inflammatory cytokines and type ...

Objective Ficolin-3 is the main initiator of the lectin pathway of complement in humans. Case reports of ficolin-3 deficient patients have suggested that ficolin-3 deficiency may be enriched in ...

Conclusion We are successfully using a “rare disease study” approach to conduct the first trial of a biologic therapy to prevent pregnancy complications in women with APS and LAC. Certolizumab appears ...

Background Very limited and old data regarding the epidemiology of juvenile-onset SLE (jSLE) are available. Our aim was to estimate jSLE incidence and mortality rate in incident cases over the period ...

Background Often, patients present with clinical symptoms and immunologic abnormalities suggestive of systemic lupus erythematosus (SLE), while not meeting classification criteria yet. This is ...

Background This study aimed to investigate the clinical characteristics, outcomes, and risk factors of patients with a rare but fatal manifestation of systemic lupus erythematosus (SLE), diffusive ...

Background Recently, vitamin D has been shown to play an important role in the immune responses, increasing evidence that it can contribute to the pathogenesis of systemic lupus erythematosus (SLE) as ...

Background Antiphospholipid syndrome (APS) is acquired thrombophilia characterized by the presence of antiphospholipid antibodies (aPL). Its main manifestations are vascular thromboses and pregnancy ...

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease with varied clinical manifestations and complex pathogenesis. SLE has a significant impact on morbidity, mortality and ...