NCAA Tournament bracket picks will feature a No. 16 seed knocking off a No. 1 seed, but two of the last six editions of March Madness have featured the ultimate bracket-busting mayhem of a No. 1 seed going down in the opening round.

Both USC and UConn have strong cases to make it to the Final Four, and win a national championship, but with Paige Bueckers starring a professional basketball career in the face, and UConn without a national title in a decade, the sense of urgency should favor the Huskies.

Here's a region-by-region look at the 2025 men's NCAA Tournament, along with Final Four and national championship predictions: