Researchers at ETH Zurich recently explained the role of a molecular complex that orchestrates production of proteins in our cells. They now show that this complex also controls the processing of ...

NUDT5 enzyme acts as a molecular scaffold that maintains metabolic balance. Inside every cell, a finely tuned metabolic network determines when to build, recycle or stop producing essential molecules.

Reducing the time and expense of engineering PROTAC degraders remains a significant challenge in the pharmaceutical industry. A PROTAC is composed of an E3 ligase ligand (E3-L), a protein of interest ...

NF2 deficiency eliminates LATS-mediated phosphorylation of YAP, allowing dephosphorylated YAP to enter the nucleus and co-activate CAD and DHODH transcription. Together, these enzymes accelerate de ...

This month's cover highlights the article Uncovering biomarkers for chronic toxoplasmosis detection highlights alter-native pathways shaping parasite dormancy by Marie G. Robert, Christopher Swale, ...

In today’s rapidly evolving scientific landscape, eliminating barriers to progress is more critical than ever. Precision medicine and targeted therapies hold great promise but are dependent on the ...

The first time Ryan Shenvi played Wordle, when the popular word-guessing game was just taking off, he remembers thinking, “Oh, we should do this for retrosynthesis.” The La Jolla–based Scripps ...

Introduction: We developed and produced a new series of 4,6-diaryl-pyrimidines 9–29 as antiproliferative agents targeting EGFR/VEGFR-2. Methods: The antiproliferative efficacy of the novel targets was ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Protein–protein interactions (PPIs) are essential in numerous biological processes and ...

For new, human-made heavy elements on the periodic table, being “too ‘big’ for your own good” often means instability and a fleeting existence. The more protons and neutrons scientists squeeze ...