Investigating how the production of insulin is regulated in fruit flies reveals surprising insights that may help to better understand how this process unfolds in humans.

Insulin is a hormone that allows glucose in the blood to enter cells, providing them with the energy to function. A lack of adequate insulin plays a key role in the development of diabetes ...

Circulating insulin binds to insulin receptors on blood vessel endothelium, leading to activation of endothelial nitric oxide synthase (eNOS), NO-mediated vasodilation and increased perfusion of ...

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Food that can support insulin sensitivity include non-starchy vegetables, whole grains, and citrus fruits. People with insulin resistance may also wish to limit sugary drinks and highly processed ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with variations in receptor function. Computational protein structure prediction ...

“Insulin resistance is caused by a buildup of fatty acids in your liver and in your muscle cells that turn off insulin receptors where insulin can’t effectively bring in glucose from the blood into ...

Summary: New research sheds light on how ketamine affects the brain by targeting a specific NMDA receptor subtype, GluN1-2B-2D. Scientists used electron cryo-microscopy to capture how ketamine binds ...

Over the past decade, the rising cost of insulin epitomized the broader systemic issue of higher healthcare out-of-pocket costs that prevented many Americans from accessing essential care.

Using human endothelial cells, they found that ADM inhibited insulin receptor phosphorylation via protein-tyrosine phosphatase 1B, reducing insulin signaling. While becoming obese, these knockout ...

The activation of insulin receptors, which are highly expressed on the luminal side of endothelial cells, induces endothelial nitric oxide (NO)-synthase (eNOS) activity. Subsequently, NO-mediated ...