More information: Michael Turewicz et al, Temporal phosphoproteomics reveals circuitry of phased propagation in insulin ...

When a molecule of insulin, a hormone, “docks” with the receptor, a complex signaling cascade is set in motion inside a cell, culminating in the cell’s uptake of insulin. The Brain Is Not ...

In the IoB, networked devices include living cells, such as insulin-producing cells. ... in turn, this triggers a signaling cascade in the cell that controls the insulin gene.

Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet. The research, published today as a Reviewed ...

A rare cell in the lining of lungs is fundamental to the organ-wide response necessary to repair damage from toxins like ...

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of Type-1 diabetes, hepatitis, ...

Ulke J, Chopra S, Kadiri OL, et al. PTPRJ is a negative regulator of insulin signaling in neuronal cells, impacting protein biosynthesis, and neurite outgrowth. J Neuroendocrinol . Published ...

When leptin binds to its receptors in these cells, it modulates insulin secretion by influencing pathways like phosphoinositide 3-kinase (PI3K) and the cyclic AMP (cAMP) pathway.

It is thought that insulin signalling controls thousands of phosphosites, ... the team found that modulating a specific protein could reverse insulin resistance in a cell-based model.

They were designed to treat diabetes, then prescribed for weight loss, and now—as researchers are finding—they might hold the secret to staving off Alzheimer’s, too.