Pregame analysis and predictions of the Seattle Mariners vs. Boston Red Sox MLB game to be played on April 23, 2025 on ESPN.

Preview the April 22 matchup between the Boston Red Sox and Seattle Mariners with odds over/under, game spread, betting lines and more.

Brayan Bello will start for the Boston Red Sox on Tuesday against Randy Arozarena and the Seattle Mariners. First pitch is at 6:45 p.m. ET for this first game in a three-game series. The Red Sox's 4.04 team ERA ranks 15th across all league pitching staffs. Mariners pitchers have a combined ERA of 3.78 ERA this year, which ranks 12th in MLB.

BOSTON — Walker Buehler pitched seven strong innings, Kristian Campbell’s base-loaded grounder rolled into right field for a two-run single and the Boston Red Sox beat the Chicago White Sox 4-2 in Boston’s annual Patriots’ Day game.

Instead of navigating road closures along the Boston Marathon route, Red Sox pitcher Walker Buehler instead took his family to a hotel prior to his Monday morning start.