Objective To confirm that metformin prevents flares in patients with SLE with low disease activity, we performed a post hoc analysis combining our previous two randomised trials.Methods Post hoc ...

Over 3 weeks, the metformin dose was increased to 1000mg before breakfast and 500mg before dinner, after which the dosage was maintained constant to the end of the 8-week double-blind period.

We already know quite a lot about metformin. It's been around for decades, and is considered a gerotherapeutic: a drug able to slow down various aging processes in the body. For example, it's been ...

Oxypurinol is a metabolite of allopurinol, a drug used to treat gout, and metformin is a first-line treatment for type 2 diabetes. Both oxypurinol and metformin enter the wastewater treatment plants ...