When a molecule of insulin, a hormone, “docks” with the receptor, a complex signaling cascade is set in motion inside a cell, culminating in the cell’s uptake of insulin. The Brain Is Not ...

More information: Michael Turewicz et al, Temporal phosphoproteomics reveals circuitry of phased propagation in insulin ...

In the IoB, networked devices include living cells, such as insulin-producing cells. ... in turn, this triggers a signaling cascade in the cell that controls the insulin gene.

In Iir −/− β-cells cultured ex vivo, INSR–IGF1R signalling was increased in response to insulin. INSR, IGF1R and IGF2R homodimers and heterodimers rapidly internalize following ligand ...

Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus. PLoS ONE , 2011; 6 (11): e28050 DOI: 10.1371/journal.pone.0028050 Cite This Page : ...

Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet. The research, published today as a Reviewed ...

Insulin signaling is certainly involved in diabetes, ... The deletion caused a 90 percent reduction in total insulin content inside the cells.

In experiments using human endothelial cells, the researchers demonstrated that adrenomedullin inhibits insulin signaling by activating a cascade that deactivates the insulin receptor.

A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated for the first time in living animals that insulin receptors in the brain can initiate signaling that regulates ...