This research finds that Insulin resistance in the general population seems likely to be caused by a series of cell-specific signaling defects some of which appear to be sex-specific. In addition ...

More information: Michael Turewicz et al, Temporal phosphoproteomics reveals circuitry of phased propagation in insulin signaling, Nature Communications (2025). DOI: 10.1038/s41467-025-56335-6 ...

Immune checkpoint inhibitors have changed the future of cancer care. These powerful treatments use the body’s own immune ...

“Insulin is essential for life, but too much of it can also be deadly,” said Dr. Michael Karin, senior author of the study ...

What is the difference between Type 1 and Type 2 diabetes? What about pre-diabetes? And how does insulin resistance factor in? Here's what to know.

Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet. The research, published today as a Reviewed ...

In experiments using human endothelial cells, the researchers demonstrated that adrenomedullin inhibits insulin signaling by activating a cascade that deactivates the insulin receptor.

Ulke J, Chopra S, Kadiri OL, et al. PTPRJ is a negative regulator of insulin signaling in neuronal cells, impacting protein biosynthesis, and neurite outgrowth. J Neuroendocrinol . Published ...

When leptin binds to its receptors in these cells, it modulates insulin secretion by influencing pathways like phosphoinositide 3-kinase (PI3K) and the cyclic AMP (cAMP) pathway.