Boehringer Ingelheim/Eli Lilly), and insulin aspart (Fiasp and NovoLog; Novo Nordisk). Similarly, total spending for all 10 drugs increased from $3.5 to $27.5 billion per year during the same period ...

Tresiba (insulin degludec) is a once-daily new-generation based insulin analogue with an ultra-long duration of action. Ryzodeg (insulin degludec / insulin aspart) contains the new-generation once ...

In line with that, our review highlights the well-accepted mechanisms of action and resistance to the therapy and ... IGF-binding protein-3; IGFR, insulin-like growth factor receptor; MAPK, ...

The mechanism of increased excretion, as with insulin resistance, is likely a downregulation of TRPM6, which leads to a decreased distal reabsorption of magnesium (14). Tacrolimus is primarily ...

The FDA approved insulin-aspart-szjj (Merilog) as the first rapid-acting insulin biosimilar product to treat adults and ...

Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...

The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

The SARS-CoV-2 pandemic interrupted much respiratory research. Respiratory clinical academics joined colleagues in providing clinical care, and global research efforts were directed to finding new ...

Patients previously treated with insulin with or without OADs had the highest baseline and final-visit rates of major hypoglycemia: 0.269 and 0.021 events/patient year, respectively. The rates of ...

It is now widely recognised that host–microbiome interactions play a major role in the control of energy metabolism and ...