The San Francisco 49ers (9-4) will face the Tennessee Titans (2-11) in Week 15 at Levi’s Stadium, with all eyes on star running back Christian McCaffrey. McCaffrey was a late addition to the injury report on Saturday with a back issue, earning a questionable designation.

Christian McCaffrey is expected to play for the 49ers vs. the Titans despite a late back “questionable” tag, per Schefter and Rapoport.

As the 49ers return from their bye and host the Tennessee Titans, the fantasy landscape for this matchup looks very different from what it would have earlier in the season. Tennessee, meanwhile, is still searching for rhythm with a rookie quarterback and a reshaped skill-position group that no longer includes Derrick Henry or DeAndre Hopkins.

The Patriots want to stay atop the AFC East when they host the Buffalo Bills to highlight today's early window of games (1 p.m. ET, CBS). Another game carries playoff implications in the AFC West with the Chargers on the road to face the Chiefs (1 p.m. ET, CBS).

The talk all off-season was that the 49ers play the worst division in football, but the NFC and the AFC South are ahead of the AFC North and NFC East in the standings. Before the year, you would have thought that the Ravens and Bengals would be much tougher than the Jaguars and Colts, but the records say differently.

San Francisco 49ers quarterback Brock Purdy delivered an encouraging toe injury update this week, saying it “feels really good” as the team comes out of its late-season bye and prepares to host the Tennessee Titans on December 14.

So if the Niners let him play out his contract, shake his hand, and watch him sign a solid $20-to-$30 (maybe $40) million-dollar deal elsewhere in free agency come the end of the 2026 season, the league office will essentially FedEx a third-round pick (fourth at worst) to Santa Clara. That’s money in the bank. That’s a free lottery ticket.