The on-again, off-again relationship between wide receiver Brandon Aiyuk and the San Francisco 49ers looks to be off again. Potentially for good this time.

Fans planning to attend the 49ers-Titans Week 15 matchup at Levi’s Stadium on Sunday should prepare for dense fog during the morning commute. Conditions should clear up later in the day, with a high temperature of 57 degrees expected, according to AccuWeather.

The San Francisco 49ers have placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season.

The wide receiver hasn't played since 2024.

Brandon Aiyuk hasn't played an NFL game since his serious knee injury in 2024. Here's why he won't be playing at all in 2025.

The San Francisco 49ers are sitting at 9-4 with four weeks left in what has been quite the season this year. They’ve dealt with injuries, another wide receiver saga, and still have managed to be in the playoff picture despite playing a number of first and second-year players this season.

The depth of the San Francisco 49ers, especially on defense, is insanely thin. They cannot afford to have a few players or more on that side of the ball out. U