Researchers say structure reveals many new ways to change PINK1, essentially switching it on, which will be "life-changing" for people with Parkinson’s disease.

Using Foldit, a protein structure prediction software ... the researchers prepared c-Myc fused PhC monomer mRNA and mixed it in a system containing cell extracts and the building units of PhC.

The structure gives some clues to the layout of functional sites (Fig. 2). The 130 kDa monomer is U-shaped ... an initially soluble protein is converted into a membrane-inserted pore, implying ...