If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.

The distinct population of endothelial cells that line blood vessels in the insulin-producing "islets" of the human pancreas ...

A model summarizing the insulin-signaling pathways in the liver, muscle, and pituitary of lean or DIO mice. Arrows indicate active signaling pathways, and an X over the arrow indicates blocked ...

A thorough examination of modern drugs that target particular receptors and metabolic pathways for glucose and fat metabolism is presented. Recent research has revealed innovative targets and ...

Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...

Sadagurski and her fellow researchers concluded that the microglial NF-κB pathway plays a critical ... transcriptome and alterations in insulin and immune signaling, were observed exclusively ...