When a molecule of insulin, a hormone, “docks” with the receptor, a complex signaling cascade is set in motion inside a cell, culminating in the cell’s uptake of insulin. The Brain Is Not ...

More information: Michael Turewicz et al, Temporal phosphoproteomics reveals circuitry of phased propagation in insulin ...

In the IoB, networked devices include living cells, such as insulin-producing cells. ... in turn, this triggers a signaling cascade in the cell that controls the insulin gene.

Cell signalling articles from across Nature Portfolio. ... insulin signalling, stress signalling, morphogen signalling, Hippo signalling, TOR signalling and integrin signalling. ...

Although this review is focused on recent findings relating insulin resistance to an early impaired insulin signaling and action in fat cells through a reduced IRS-1/GLUT4 expression, ...

Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus. PLoS ONE , 2011; 6 (11): e28050 DOI: 10.1371/journal.pone.0028050 Cite This Page : ...

Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet. The research, published today as a Reviewed ...

In experiments using human endothelial cells, the researchers demonstrated that adrenomedullin inhibits insulin signaling by activating a cascade that deactivates the insulin receptor.

It is thought that insulin signalling controls thousands of phosphosites, ... the team found that modulating a specific protein could reverse insulin resistance in a cell-based model.

A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated for the first time in living animals that insulin receptors in the brain can initiate signaling that regulates ...