More information: Michael Turewicz et al, Temporal phosphoproteomics reveals circuitry of phased propagation in insulin ...

Cell signalling articles from across Nature Portfolio. ... insulin signalling, stress signalling, morphogen signalling, Hippo signalling, TOR signalling and integrin signalling. ...

Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet. The research, published today as a Reviewed ...

In experiments using human endothelial cells, the researchers demonstrated that adrenomedullin inhibits insulin signaling by activating a cascade that deactivates the insulin receptor.

Ulke J, Chopra S, Kadiri OL, et al. PTPRJ is a negative regulator of insulin signaling in neuronal cells, impacting protein biosynthesis, and neurite outgrowth. J Neuroendocrinol . Published ...

Both type 1 and type 2 diabetes possess a significant genetic component.

It is thought that insulin signalling controls thousands of phosphosites, ... the team found that modulating a specific protein could reverse insulin resistance in a cell-based model.

When leptin binds to its receptors in these cells, it modulates insulin secretion by influencing pathways like phosphoinositide 3-kinase (PI3K) and the cyclic AMP (cAMP) pathway.