The insulin receptor (IR) is a prototypical receptor tyrosine kinase that orchestrates critical cellular processes, including metabolism, cell growth and differentiation. Activation of the IR involves ...

Our glycaemic balance is based on the ability of the pancreatic beta cells to detect glucose and secrete insulin to maintain our blood sugar levels. If these cells malfunction, the balance is broken, ...

Investigators at the Helmholtz Institute have shown that inceptor, an inhibitor of the insulin signaling pathway, acted by binding insulin and targeting it for degradation. “Insulin was discovered 100 ...

Scientists have successfully transplanted gene-edited insulin-producing cells into a man with type 1 diabetes—allowing him to ...

The results were very promising. In just three months, the number of human beta cells grew by 700%. The mice’s diabetes ...

Argentine scientists have identified a mechanism that allows pancreatic beta cells, which produce insulin, to become ...

McGill University researchers have identified a brain function that helps explain why childhood stress raises metabolic ...

Groundbreaking Harvard research reveals gut-produced molecules significantly influence obesity and blood sugar control. These ...

* First-ever human transplant of gene-edited insulin-producing cells without immune rejection * Patient produced natural insulin for 12 weeks with no //immunosuppressants * Marks a breakthrough step ...

A new therapy for type 1 diabetes could nix the need for insulin injections. Just a single infusion of lab-grown pancreatic cells let patients’ bodies make all the insulin they needed, scientists ...

NEW YORK — Imagine a world where diabetes could be treated with a simple pill that essentially reprograms your body to produce insulin again. Researchers at Mount Sinai have taken a significant step ...